Tinderbox with a pen
Scott Price's mouse broke, so he tried using a Wacom pen he'd set aside. He found it worked better than he expected for Tinderbox and FileMaker:
But they've really improved the drivers, and this time I was forced to use it long enough to get used to it. And I won't go back soon because I'm really enjoying the physical sensation of using a pen for my text-work. It's thrilling to drag windows around with the pen like I'm drawing, and it feels so right to make a highlighter motion over text, then drag a link-arrow (in Tinderbox) from the text to another note to make a link. I made the main button on the pen into ctrl-click and it feels like I am really grabbing links and icons and pulling the contextual menu out of them.